Amarna Therapeutics is a privately held, pre-clinical biotech company developing transformative, potentially curative gene therapies for a range of both rare and prevalent diseases.
The company is pioneering the development of gene therapies based on simian virus 40 (SV40), a macaque polyoma virus to which humans are immunologically naïve. Amarna has created a proprietary production cell line (SuperVero™) that, for the first time, makes it possible to produce SV40-derived vectors suitable for therapeutic use.
Combining SuperVero™ with its genetically engineered Nimvec™ viral vector, the company’s fully-integrated gene therapy platform is truly unique in its intrinsic capability to deliver transgenes without eliciting immune responses to the vector nor to the transgene product.
Leveraging this ‘natural’ non-immunogenicity feature of its gene delivery system in humans, Amarna is developing a broad pipeline of safe, effective and durable gene therapies focused on genetic disorders, autoimmune diseases and chronic inflammation.
Founded in 2008, Amarna’s head office is based in Leiden Bio Science Park, the Netherlands, with a research subsidiary located in Seville, Spain.
Henk is a Physician Scientist with more than 15 years of experience in the pharmaceutical industry and clinical Development. This includes different expert roles as a member of the submission teams that reached worldwide approvals of Rasitrio™, Entresto™, and Kisqali™. He has broad cross-indications experience in clinical outsourcing GCP inspections and CAPA implementation/execution. Henk is currently the CEO and Medical Director of Amarna Therapeutics.
Peter has a virology background and has been active in R&D for more than twenty-five years.
Peter’s academic career started as a Virologist at the Wageningen University in The Netherlands, where he obtained his PhD in 1991. In 1991 he joined Novartis Seeds where he held several research management positions in the field of plant biotechnology. He is a co-founder of Phytovation B.V., formerly active in biopharmaceuticals and vaccine production, and of its subsidiary Viruvation B.V., which was active in developing therapeutic AIDS and HCV vaccines.
Throughout his career Peter has worked on applications of virus-associated technologies. He has a long-standing expertise in virology, molecular & cell biology, immunology and is highly experienced in molecular cloning activities, tissue culture of mammalian cells and production of (recombinant) virus particles in mammalian cell systems.
Peter is the (co-) author of more than fifty peer reviewed scientific articles. Next to this, he is the company’s intellectual property (IP) manager. Peter has a longstanding expertise with IP matter as (co-) inventor of more than twelve different awarded patents and patent applications.
Henk is a Physician Scientist with more than 15 years of experience in the pharmaceutical industry and clinical Development. This includes different expert roles as a member of the submission teams that reached worldwide approvals of Rasitrio™, Entresto™, and Kisqali™. He has broad cross-indications experience in clinical outsourcing GCP inspections and CAPA implementation/execution. Henk is currently the CEO and Medical Director of Amarna Therapeutics.
Thomas was the co-founder of Recipharm AB, a Swedish pharmaceutical contract development and manufacturing company, in 1995. Under his leadership, the organization grew to be a major player with approx. 9000 employees, at 30 facilities located in ten countries, offering pharmaceutical companies full service by taking products all the way from early development to commercial production. Thomas is currently President at life-science investor Flerie Invest and at the Board of several private and public companies including Kahr Medical Ltd, Prokarium Ltd, Toleranzia AB, Nanologica AB, NorthX Biologics AB and Sixera Pharma AB.
Thomas has a graduate degree from Linköping Institute of Technology, Sweden.
Peter has a virology background and has been active in R&D for more than twenty-five years.
Peter’s academic career started as a Virologist at the Wageningen University in The Netherlands, where he obtained his PhD in 1991. In 1991 he joined Novartis Seeds where he held several research management positions in the field of plant biotechnology. He is a co-founder of Phytovation B.V., formerly active in biopharmaceuticals and vaccine production, and of its subsidiary Viruvation B.V., which was active in developing therapeutic AIDS and HCV vaccines.
Throughout his career Peter has worked on applications of virus-associated technologies. He has a long-standing expertise in virology, molecular & cell biology, immunology and is highly experienced in molecular cloning activities, tissue culture of mammalian cells and production of (recombinant) virus particles in mammalian cell systems.
Peter is the (co-) author of more than fifty peer reviewed scientific articles. Next to this, he is the company’s intellectual property (IP) manager. Peter has a longstanding expertise with IP matter as (co-) inventor of more than twelve different awarded patents and patent applications.
A Professor of Pathology, Anatomy and Cell Biology at Thomas Jefferson University and the Sidney Kimmel Cancer Center in Philadelphia at Thomas Jefferson University, Philadelphia, Pennsylvania, for the last 30 years, Professor Strayer is also an attending pathologist at Thomas Jefferson University-Affiliated Hospitals.
His career in clinical research has spanned immunology, pathology, virology and gene therapy, including studying the mechanisms of viral oncogenesis and virus-related immunosuppression and the study of clinical and immunological aspects of pulmonary surfactant as therapy for respiratory distress syndrome and the development. In applied virology and translational clinical trials his work has focused on viral gene delivery vehicles for potential application in treating diverse human diseases. This involved studying virus-host cell interactions and the impact on replication. His laboratory re-engineered simian virus-40 (SV40) for use as a gene delivery vehicle including exploiting its ability to evade the immune system. His team has modified the SV40 genome to carry genes of therapeutic interest, and used the resulting vectors effectively to deliver those genes to many cell types and organs, including bone marrow stem cells, neurons, liver, lung and other organs, demonstrating that repeated injection of SV40-derived vectors in vivo is feasible, effective and safe.
The significance of his work in gene therapy led to his appointment as Founding Chair of the NIH Gene and Drug Delivery Study Section, and countless presentations at national and international meetings.
He has held prior positions at Washington University, St. Louis, Missouri, the University of California, San Diego, Yale University and the University of Texas, Houston. He is the author over 150 original articles, over 200 abstracts and over 75 invited and review articles, and books, and is editor of a major textbook of Pathology (Rubin's Pathology: Mechanisms of Human Disease), published by Wolters-Kluwer.
He has an undergraduate degree in chemistry, from Cornell University, Ithaca, New York and received his PhD in immunology and MD degree from the University of Chicago, Chicago, Illinois.
Bernd has over 25 years' experience in pharmaceutical research and drug development, having held leadership roles at Merck/Merck Serono, Sanofi-Aventis, Aventis and Hoechst Marion Roussel. He has expertise in a broad range of disease areas including oncology, immuno-oncology, immunology, neurological disorders and cardiometabolic diseases. In the eight years to 2013, he worked at Merck/Merck Serono, becoming a member of the Board and Executive Vice-President, Global Research & Early Development. He was responsible for a budget of 1 billion euros and a global team of over 2,500 associates. In his last three years at Merck Serono, he led the successful growth of the company's R&D portfolio, with over 70 programmes, doubling the number of Phase II assets in this period. Bernd is currently Chairman of OMEICOS Therapeutics and GeneQuine Biotherapeutics and a board member of Redx, BioMedX, Enlivex Therapeutics as well as an advisor to the board of KAHR Medical.
Bernd was awarded his PhD in Biochemistry and Physiological Chemistry from the University of Konstanz, Germany.
Maarten is a bio-entrepreneur working primarily in oncology and rare diseases. He did basic research at Lund University, Harvard Medical School and Uppsala University. He worked as a sell-side analyst at two investment banks: Aragon and Swedbank Markets. For the last 15+ years he has been involved in clinical development at Sanofi and Sobi, before co-founding Cormorant Pharmaceuticals. Cormorant brought a mAb against IL-8 into the clinic as an immune-oncology agent and was sold to BMS in 2016. In the same year he co-founded Buzzard Pharmaceuticals, where a potent IL-1 inhibitor is being developed as an immune oncology agent. He also serves as CEO of Sixera Pharma, developing a NCE treatment for the rare skin disease Nethertons, and is VP Medical Strategy and Innovation at Camurus. He currently also serves on the boards of Atrogi, OxThera, Cavis Technologies and Beactica.
Maarten holds a MD as well as a PhD from Lunds University, Sweden.
Ted is Venture Partner in Flerie Invest, a Swedish investment firm and investor in Amarna, with biotech investments in Sweden, the UK, the Netherlands and Israel. He is also the CEO of Prokarium, a London-based biotech developing microbial immunotherapies and vaccines. Ted has held a clinical research position at Sahlgrenska University Hospital and has worked as a strategy consultant at Sweden’s Royal Academy of Engineering Sciences, where he coordinated the country’s national innovation strategy. He is an active member of the UK BioIndustry Association (BIA) and has served on the Management Board of the international Bacterial Vaccines Network (BactiVac). He also co-founded and continues to serve on the board of Tekiu, an international knowledge transfer broker active within healthcare, environmental tech and smart cities.
Ted holds a PhD in Biotechnology & Immunology from the university of Guelph, Canada.
Pim is the CEO and co-founder of the Dutch IT company Schuberg Philis and has been one of Amarna’s pioneering informal investors for over 10 years. He was managing director in the Netherlands of SiteSmith Inc., a US-based Internet infrastructure management services company. In 2000 SiteSmith Inc. was acquired by Metromedia Fiber Network Inc. (MFN) in a transaction valued at approximately $1.4 billio, following which he became Senior Vice President of MFN’s European Region. In a management buyout by Pim and two partners in 2003 the Benelux subsidiary of MFN Inc. became Schuberg Philis. Before this, Pim held several senior executive positions at the Dutch IT companies Pink Elephant and PinkRoccade (now part of KPN).
Pim holds a master’s degree in Computer Engineering and Economics from the Hogeschool IJsselland, Netherlands.
Guillaume is the CFO of the Netherlands based MercachemSyncom, a leading European mid-sized contract research organization. Guillaume is a seasoned senior biotech executive, that has been working in the healthcare industry for most of his career. He held positions at Merck, Sharpe & Dohme, as well as served as Chief Financial Officer (CFO) of Wolters Kluwer Health. He also worked as CFO for Galapagos between 2009 and 2014.
Guillaume holds a master’s degree in Economics from the University of Maastricht, Netherlands and is a Certified Registered Accountant.
Markwin is an independent entrepreneur with 25 years of experience, in the fields of research, development, operations and management. After transferring from the US academical to the Dutch biopharmaceutical sector, Markwin served, among several other management positions, four years as CSO at the Dutch biotech company AM-Pharma, with responsibility for R&D. In 2013 he consulted with the Dutch biotech T-Cell Factory (TCF) where he played a key role in the acquisition of the company to form Kite Pharma EU B.V. Markwin following joined Kite in 2015 as VP Operations where he managed the R&D of new T cell receptors alongside the implementation of Kite’s new manufacturing facility for cell therapy in the Netherlands. In addition, Markwin is former chairman of the supervisory board of HollandBio, the branch association for Biotech in the Netherlands and supervisory board member at ISA Pharmaceuticals in Leiden.
Markwin was awarded a PhD in Molecular Immunology from Leiden University in the Netherlands.
Ben Samelson-Jones, MD, PhD is an Assistant Professor of Pediatrics and a member of the Gene Therapy and Vaccine (GTV) Graduate Program at the University of Pennsylvania. He is an attending pediatric hematologist and member of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia (CHOP). And he is the Associate Director of the Clinical In Vivo Gene Therapy group at CHOP.
He provides medical care for patients with blood diseases with a special interest in hemophilia and other bleeding disorders. He is a principal investigator on clinical gene therapy trials for hemophilia A and hemophilia B and has translational laboratory focused on developing novel treatments for bleeding disorders. His laboratory is supported by funding from the National Heart, Lung, and Blood Institute, the National Hemophilia Foundation, as well as by a number of sponsored research agreements with biotech partners. His research includes defining the biochemical mechanism of the hyperactivity of factor IX (FIX) Padua, which is used in all current gene transfer clinical trials for hemophilia B. He has published over 30 peer-reviewed papers including in The New England Journal of Medicine, Blood, and Molecular Therapy and filed for three patents. He is an abstract reviewer for the American Society of Hematology (ASH) and the International Society of Thrombosis and Haemostasis (ISTH) and is currently a member of the Translational Research Committee of the American Society of Gene and Cell Therapy (ASGCT).
He received his undergraduate degree in physics from Amherst College and his MD and PhD from Albert Einstein College of Medicine. He completed residency at the Children’s National Medical Center and fellowship at CHOP.
Sybrand has a background in engineering and has worked in the biotechnology field for over 20 years. He has been responsible for the upstream process development and technology transfer for several phase I/II (viral vector) and phase III (antibody) projects. Sybrand joined Amarna in January 2011 and is responsible for ensuring that all projects progress smoothly and meet their timelines and milestones.
Thijs is a biotechnologist with over 10 years of experience in making creative experimental laboratory setups. His work focuses on preclinical process development, translating research concepts into viable clinical trial manufacturing campaigns. Thijs holds a MSc degree in biotechnology and a PhD in Bioprocess engineering from Wageningen University. Additionally, he has authored multiple CMC related scientific publications and patents.
Jeroen has over 25 years of experience in R&D and a background in molecular biology. After obtaining his BSc degree in Medical Biology, he started his career at Novartis Seeds, followed by Uniqure, Viruvation B.V., and Amarna Therapeutics B.V.
Throughout his career, Jeroen has gained expertise in recombinant DNA, cell culture, and production of viral vector particles. At Amarna Therapeutics B.V., he helped select the SuperVero cell line, established the first steps in the Nimvec™ production process, and developed product-specific assays. As his preferred area of focus is analytics, he currently holds the position of Team Lead for Analytical Development at Amarna Therapeutics B.V. Additionally, he is the company’s Bio Safety Officer.
Miguel has strong experience in gene therapy and immunology. He has been active in R&D field for more than 20 years. He graduated from University of Granada (Spain) in 2001 where he developed his PhD in the gene therapy of Wiskott-Aldrich Syndrome, a primary immunodeficiency. He obtained his PhD with Cum Laude honors.
During his PhD he visited relevant labs in London (Great Ormond Street Children Hospital) and in Rochester, Minnesota (Mayo Clinic). Later, he developed his postdoc research at Temple University in Philadelphia, supervised by Doina Ganea, focused on gene therapy of multiple sclerosis (autoimmune disease).
Miguel background includes development of viral-based vectors for gene therapy, development of gene expression systems, work with mouse models of autoimmune and inflammatory diseases, molecular biology, stem cell biology, gene editing and immunology. He is (co-) author of more than 40 publications and several patents as a (co-) inventor and he is lecturer at the Master degree of Human Genetics at the University of Granada.
He joined Amarna in 2013 to lead the research activities of the company related to the evaluation of Amarna’s vectors in animal models of human diseases, in Spain. Miguel has contributed to settle Amarna in Spain by opening its first laboratory facility in Sevilla.
Didac Mauricio, MD PhD, is Director of the Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau in Barcelona, and Professor with the Faculty of Medicine, University of Vic & Central University of Catalonia (UVic/UCC).
He is leading the Diabetes Research Group at his current institution, that belongs to the excellence diabetes research network CIBER of Diabetes and Associated Metabolic diseases (CIBERDEM), Instituto de Salud Carlos III, in Spain. He has published over 330 peer-reviewed articles (WoS H-index: 52), and has contributed to multiple books. He has received the highest awards from the Spanish Society of Diabetes and the Spanish Society of Endocrinology & Nutrition. He is currently vice-president of the Spanish Society of Endocrinology & Nutrition (term expiring 2025). He has also served as a member in several local and international committees. D. Mauricio has been principal investigator of multiple research projects funded by national and international agencies. He keeps a strong interest on current clinical issues in diabetes management, including randomised clinical trials and clinical research on diabetic complications, as well as in studies on real-world evidence.
D. Mauricio is a member of the editorial board of several scientific journals and is currently a member of the Guideline Oversight Committee of the European Association for the Study of Diabetes.
Gustavo Frechtel is a MD who graduated at the University of Buenos Aires, Argentina and a Ph.D. in Genetics and Molecular Biology of Diabetes at the same University. He is the Head of the Nutrition and Metabolism Division at the Clinical Hospital, University of Buenos Aires. He is also Professor in Nutrition and Metabolism at the School of Medicine, University of Buenos Aires. He is a researcher at the National Scientific and Technological Research Council (CONICET), where he directs a research group in immunology and genetics of diabetes and metabolism integrated by 10 basic researchers ‒biologists and biochemists‒ and 10 MDs specialized in diabetes and metabolism.
He is the director of the Clinical Research Center, site which has participated in 35 protocols of the Pharmaceutical Industry, aimed at drug research in Diabetes and Obesity. He has directed 15 fellows, 11 of whom obtained their PhD degrees. He has published 65 papers in international journals and an equal number in national journals. He is a reviewer at several international journals. He has been a speaker at more than 100 talks at national and international congresses.
Luiza Caramori, MD, MSc, PhD is a Staff Physician at the Institute of Endocrinology and Metabolism at Cleveland Clinic, and at the Department of Cardiovascular and Metabolic Sciences, Lerner research Institute, Cleveland, and an Adjunct Associate Professor at the University of Minnesota. Dr. Caramori received her MD degree in Brazil (1990) and did her fellowships in Endocrinology and Diabetes in Brazil and in the United States. After receiving her Master’s in Sciences degree (1997), Dr. Caramori completed her research training in diabetic kidney disease (DKD) at the University of Minnesota (1998-2002), initially sponsored by the Brazilian government and later by JDRF. Dr. Caramori’s clinical passion lies in providing outstanding care to patients with diabetes. She was the director of the Joint Commission Accredited Inpatient Diabetes Service at the University of Minnesota Medical Center between 2015-2022, when she relocated to Cleveland Clinic and the Lerner Research Institute.
Dr. Caramori’s main research interests include studies on the relationships between kidney structure and function, early molecular and structural predictors of DKD, and clinical trials studying repurposed and new drugs for the prevention and treatment of DKD. Dr. Caramori has authored more than 60 publications in peer- reviewed journals and 20 book chapters. She has been funded by grants from the National Institutes of Health (NIH), JDRF, and the National Kidney Foundation (NKF) of Minnesota, among others. Currently, Dr. Caramori is the principal investigator of NIH R01 grant to study protective factors in DKD and the Co-PI of a NIH U01 grant as part of the Kidney Precision Medicine Project (KPMP).
Dr. Caramori served as Chair for the diabetic nephropathy subcommittee for the American Diabetes Association (ADA) Scientific Sessions (2018-2020). She was a member of the NKF - Kidney Disease Outcomes Quality Initiative (KDOQI) work group - and helped develop the 2007 Clinical Practice Guidelines and Recommendations for Diabetes and CKD. She is also a member of the Kidney Disease: Improving Global Outcomes (KDIGO) task force. She also volunteers her time toward important initiatives of JDRF, ADA, and American Society of Nephrology.